Human axillary extracts: Analysis of compounds from samples which influence menstrual timing
G Preti1, W B Cutler, C M Christensen
1Monell Chemical Senses Center, 3500 Market Street, 19104, Philadelphia, PA.
Journal of Chemical Ecology
|December 5, 2013
Summary
Human axillary secretions contain steroids like androstenol and dehydroepiandrosterone sulfate, which vary with sex and menstrual cycle phase. These compounds may influence human reproductive physiology and scent.
Area of Science:
- Human reproductive endocrinology
- Chemosensory signaling
Background:
- Previous research suggests human axillary secretions influence menstrual cycles and fertility.
- The chemical composition of these secretions, particularly steroids, is not fully understood.
Purpose of the Study:
- To quantify specific steroids (androsterone sulfate, dehydroepiandrosterone sulfate, androstenol) in male and female axillary secretions.
- To investigate potential variations in steroid concentrations related to sex and the menstrual cycle.
Main Methods:
- Quantitative analysis using gas chromatography-mass spectrometry (GC-MS).
- Examination of male and female axillary secretion extracts.
Main Results:
- Androstenol concentrations varied, with males showing higher production at certain times and females exhibiting menstrual cycle-related variations (peak in mid-follicular phase).
- Dehydroepiandrosterone sulfate concentrations were significantly higher in males than females.
- Aliphatic acids (C2-C18) were identified, with volatile members potentially contributing to odor.
Conclusions:
- Axillary steroid concentrations differ between sexes and fluctuate with the female menstrual cycle.
- These findings provide insights into the chemical basis of potential chemosensory communication in humans.
