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Related Experiment Video

Updated: May 5, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

Screening for preeclampsia pathogenesis related genes.

Y-H Yan¹, P Yi, Y-R Zheng

¹Department of Obstetrics and Gynecology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China. 172535131@qq.com.

European Review for Medical and Pharmacological Sciences

|December 5, 2013

Summary

Preeclampsia is linked to altered gene expression in placental tissue, potentially regulated by DNA methylation. This study identified key genes involved in preeclampsia pathogenesis, offering insights into disease mechanisms.

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Last Updated: May 5, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Area of Science:

Genomics
Epigenetics
Obstetrics

Background:

Preeclampsia poses significant risks to maternal and infant health.
The underlying mechanisms of preeclampsia pathogenesis are not fully understood.

Purpose of the Study:

To identify genes associated with preeclampsia using gene array technology.
To investigate the role of epigenetic modifications, specifically DNA methylation, in regulating these genes.

Main Methods:

Analysis of placental tissue from preeclampsia patients.
Utilized DNA methylation arrays and gene expression microarrays.
Investigated the correlation between gene methylation and expression levels.

Main Results:

Identified over ten genes with significantly altered expression in preeclampsia placental tissue.
Discovered more than ten genes exhibiting concurrent changes in expression and methylation levels.
Validated gene expression changes for CUEDC1 and DHX34, consistent with prior research.

Conclusions:

Preeclampsia occurrence is closely associated with differential gene expression.
DNA methylation may play a crucial regulatory role in the development of preeclampsia.