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Related Experiment Videos

Shared epitopes between mycobacteria and other microorganisms.

C J Thorns, J A Morris

    Research in Veterinary Science
    |September 1, 1986
    PubMed
    Summary
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    Monoclonal antibodies revealed shared epitopes between various pathogens and mycobacteria. Antibodies recognizing these cross-reactive epitopes are common in normal animal sera, suggesting pre-existing immunity.

    Area of Science:

    • Immunology
    • Microbiology
    • Pathogen Antigen Discovery

    Background:

    • Monoclonal antibodies are crucial tools for identifying specific antigenic determinants (epitopes).
    • Mycobacterial antigens are known to elicit complex immune responses.
    • Cross-reactivity between antigens from different microorganisms can complicate serological diagnostics and vaccine development.

    Purpose of the Study:

    • To identify conserved epitopes shared among diverse microbial pathogens and mycobacteria.
    • To investigate the prevalence of antibodies against these cross-reactive epitopes in normal sera.

    Main Methods:

    • Utilized monoclonal antibodies to probe antigens from bacteria, parasites, and fungi.
    • Compared identified epitopes with known mycobacterial epitopes.

    Related Experiment Videos

  • Screened normal mammalian and avian sera for the presence of antibodies targeting these cross-reactive epitopes.

    • Main Results:

    • Identified shared epitopes between antigens of various bacteria, parasites, and fungi, and mycobacterial antigens.
    • Detected antibodies against many of these cross-reacting epitopes in sera from healthy mammals and birds.

    Conclusions:

    • Conserved epitopes exist across a range of pathogens, including mycobacteria.
    • Natural exposure or other factors lead to pre-existing antibodies against these shared epitopes in normal sera.
    • These findings have implications for understanding host-pathogen interactions and developing broadly protective vaccines or diagnostic tools.