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Updated: Dec 28, 2025
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3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
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The Lateral Ventricles: A Detailed Review of Anatomy, Development, and Anatomic Variations
C L Scelsi1, T A Rahim2, J A Morris2
1From the Departments of Radiology (C.L.S., T.A.R., J.A.M., G.J.K.) cscelsi@augusta.edu.
AJNR. American Journal of Neuroradiology
|February 22, 2020
Summary
Radiologists must recognize normal variations in cerebral ventricular anatomy. Understanding these variations is crucial for accurate interpretation of neuroimaging and avoiding misdiagnosis of pathology.
Area of Science:
- Neuroanatomy
- Neuroradiology
- Medical Imaging
Background:
- Cerebral ventricles historically linked to soul and executive functions.
- Early neuroradiology used ventricular alterations to detect mass effect or volume loss.
- Modern high-resolution imaging reveals anatomical variations more readily.
Purpose of the Study:
- To review the anatomy and development of the lateral ventricles.
- To discuss common and significant ventricular variations.
- To enhance radiologists' awareness of normal variants versus pathology.
Main Methods:
- Review of anatomical and developmental literature on cerebral ventricles.
- Analysis of imaging findings related to ventricular variations.
- Discussion of clinical significance and radiologic interpretation.
Main Results:
- Detailed description of lateral ventricle anatomy and development.
- Identification and categorization of several ventricular variations.
- Emphasis on the importance of distinguishing normal variants from pathological changes.
Conclusions:
- Awareness of ventricular anatomical variations is essential for accurate radiological interpretation.
- Normal variants can be mistaken for pathology if not recognized.
- Further investigation into the clinical significance of ventricular variations is ongoing.
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