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Malaria in children--prevention and management.
Angela Dramowski, Lisa Frigati, Helena Rabie
1Department of Paediatrics and Child Health, Division of Paediatric Infectious Diseases, Tygerberg Children's Hospital, Stellenbosch University, South Africa. dramowski@sun.ac.za.
Infectious Disorders Drug Targets
|December 6, 2013
Summary
Effective malaria prevention and treatment are crucial for children in Sub-Saharan Africa. This review summarizes recent pediatric trial data on malaria interventions, highlighting challenges like drug resistance.
Area of Science:
- Global Health
- Pediatric Infectious Diseases
- Tropical Medicine
Background:
- Malaria remains a leading cause of childhood mortality in Sub-Saharan Africa.
- Despite progress, effective intervention coverage is limited in high-burden regions.
- Some nations have reduced child malaria deaths using modern prevention and treatment strategies.
Purpose of the Study:
- To provide pediatric clinicians in resource-limited settings with a summary of recent pediatric trial data.
- To review current malaria treatment and prevention interventions for children.
- To address the threat of antimalarial drug resistance.
Main Methods:
- Review of recent pediatric clinical trials on malaria interventions.
- Synthesis of data on treatment efficacy and tolerability.
- Analysis of emerging antimalarial drug resistance patterns.
Main Results:
- Artemisinin-based combination therapies, including artesunate, are highly effective and well-tolerated in children.
- Several alternative antimalarial treatments are available.
- The emergence of drug resistance, particularly to artemisinins, poses a significant threat to malaria control.
Conclusions:
- Continued vigilance and adaptation of treatment strategies are necessary to combat malaria in children.
- Effective implementation of evidence-based interventions is key to reducing childhood malaria mortality.
- Addressing antimalarial drug resistance is critical for sustained malaria control efforts.
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