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Fish in chips: an automated microfluidic device to study drug dynamics in vivo using zebrafish embryos
Chunhong Zheng1, Hongwei Zhou, Xinxing Liu
1Biodynamic Optical Imaging Center (BIOPIC), and College of Engineering, Peking University, Beijing 100871, China. yanyi@pku.edu.cn.
Chemical Communications (Cambridge, England)
|December 6, 2013
Abstract:
Interference of the Hedgehog (Hh) signaling pathway by cyclopamine leads to abnormal embryonic development. We monitor this dynamical drug effect in zebrafish embryos with highly precise microenvironment control using an integrated microfluidic device. This chip-based platform, which is programmable and automated, greatly facilitates the accuracy and reproducibility of the in vivo assays.
