[Physico-chemical and biological properties of a new plasma substitute based on hydroxyethylated starch]

Samples of hydroxyethylstarch of M 100-160 kDa, Mn 50-60 kDa and substitution degree 0.6-0.7 were prepared and characterized. Hydroxyethylstarch was shown to be susceptible to cleavage by amylolytic enzymes. All samples of hydroxyethylstarch at 2-4% concentration were compatible with perfluorohydrocarbon emulsion "Perftoran" and exhibited high haemodynamic efficiency. The 6 and 10% solutions of hydroxyethylstarch in 0.9% aqueous sodium chloride normalized haemodynamics in massive blood losses. Hydroxyethylstarch was completely removed from blood-stream. The preparations were shown to be nontoxic.