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Deep brain stimulation for tremor resulting from acquired brain injury
H A Sitsapesan1, P Holland1, Z Oliphant2
1Oxford Functional Neurosurgery and Experimental Neurology, Oxford University, Oxford, Oxfordshire, UK Nuffield Department of Surgical Sciences, Oxford University, Oxford, Oxfordshire, UK.
Objectives:
To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI).
Methods:
A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale.
Results:
VOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia.
Conclusion:
VOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.
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