Related Experiment Video
Updated: May 5, 2026

Author Spotlight: Advancing 3D Coculture Systems with PVA-PCL Nanofibrous Membranes
Published on: December 27, 2024
Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer
Toshinori Fujie1, Yoshihiro Mori, Shuntaro Ito
1WPI-Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, 980-8577, Japan; Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, TWIns, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan.
Abstract:
Like a carpet for cells, micropatterned polymeric nanosheets are developed toward local cell delivery. The nanosheets direct morphogenesis of retinal pigment epithelial (RPE) cells and allow for the injection of an engineered RPE monolayer through syringe needles without the loss of cell viability. Such an ultrathin carrier has the promise of a minimally invasive delivery of cells into narrow tissue spaces.

