Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.4K
1.4K
Abnormal Proliferation02:23

Abnormal Proliferation

4.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

2.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leveraging multimodal cancer immunotherapy to amplify the efficacy of oncolytic viruses.

Experimental hematology & oncology·2026
Same author

A CDK4/6 inhibitor-armed oncolytic adenovirus reverses T cell exhaustion through the Rb-p65-CCL5 pathway and potentiates the antitumor activity of anti-PD-1 or CAR-T therapy in colorectal cancer.

Frontiers in immunology·2026
Same author

An ICOSL-armed oncolytic adenovirus activates CD4<sup>+</sup> T cell to potentiate antitumor immunity and synergizes with anti-PD-1 or CAR-T cell therapy in colorectal cancer.

BMC medicine·2026
Same author

Uric acid promotes dietary lipid absorption through microbiome and metabolomic remodeling via a liver-gut endocrine axis.

Cell host & microbe·2026
Same author

Re-balancing immunity with CRISPR-Cas9: Novel strategies for cancer and autoimmune disorders.

Biotechnology advances·2026
Same author

The commensal microbiome in respiratory tract tumors: From oncogenic mechanisms to clinical translation.

Journal of advanced research·2026
Same journal

Effect of Endoscopic Retrograde Appendicitis Therapy on Postoperative Gastrointestinal Function in Patients With Chronic Fecalith Appendicitis.

Gastroenterology research and practice·2026
Same journal

Divergent Trajectories of the Burden of MASLD Attributable to High Fasting Plasma Glucose in China and Globally: A GBD Study 1990-2021 and Projections to 2046.

Gastroenterology research and practice·2026
Same journal

From "Monarch, Minister, Assistant, and Envoy" to "Microbial Dialogue": A Review of Novel Mechanisms by Which Chinese Herb Pairs Improve Metabolic Diseases Through Gut Microbiota Metabolic Regulation.

Gastroenterology research and practice·2026
Same journal

Effects of Aging on Correlation of Striated Esophageal and Pharyngeal Deglutitive Motor Function.

Gastroenterology research and practice·2026
Same journal

RETRACTION: "Influence of Rosiglitazone on the Expression of PPAR<i>γ</i>, NF-<i>κ</i>B,and TNF-<i>α</i> in Rat Model of Ulcerative Colitis".

Gastroenterology research and practice·2026
Same journal

High Prevalence of Sarcopenia in Noncirrhotic Women With Primary Biliary Cholangitis: A Comparative Study of Clinical Characteristics and Risk Factors.

Gastroenterology research and practice·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

5.7K

PP2A-Mediated Anticancer Therapy.

Weibo Chen1, Zhongxia Wang, Chunping Jiang

  • 1Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China ; Jiangsu Province's Key Medical Center for Hepatobiliary Surgery, Nanjing, Jiangsu 210008, China.

Gastroenterology Research and Practice
|December 6, 2013
PubMed
Summary
This summary is machine-generated.

Protein phosphatase 2A (PP2A) regulates crucial cell functions and its alterations are linked to cancer. Targeting PP2A offers potential for novel anticancer therapies, particularly for digestive system cancers.

More Related Videos

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.8K
Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
15:53

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on: August 21, 2013

14.7K

Related Experiment Videos

Last Updated: May 5, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

5.7K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.8K
Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
15:53

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on: August 21, 2013

14.7K

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • Protein phosphatase 2A (PP2A) is a key mammalian serine/threonine phosphatase family.
  • PP2A regulates diverse cellular processes including signaling, cell cycle, and apoptosis.
  • Dysregulation of PP2A is increasingly correlated with human diseases, notably cancer.

Purpose of the Study:

  • To review the structure and function of PP2A.
  • To explore cancer-associated mutations in PP2A subunits.
  • To discuss therapeutic strategies targeting PP2A for anticancer therapy, focusing on digestive system cancers.

Main Methods:

  • Literature review of PP2A structure and function.
  • Analysis of studies linking PP2A alterations to cancer.
  • Examination of therapeutic approaches targeting PP2A in cancer treatment.

Main Results:

  • PP2A comprises catalytic, scaffolding, and regulatory subunits, with alterations linked to malignancies.
  • Emerging therapeutic agents aim to inhibit PP2A or directly activate its function.
  • Restoring or reactivating PP2A shows promise in preclinical and clinical settings.

Conclusions:

  • PP2A is a critical regulator of cellular functions with significant implications in cancer.
  • Targeting PP2A offers a promising avenue for developing novel anticancer treatments.
  • Further research into PP2A modulation is essential for advancing digestive system cancer therapy.