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W. W. "Mo" Cleland: a catalytic life.
Debra Dunaway-Mariano1, Hazel M Holden, Frank M Raushel
1Department of Chemistry and Chemical Biology, University of New Mexico , Albuquerque, New Mexico 87131, United States.
Biochemistry
|December 7, 2013
Summary
Professor W. Wallace Cleland, a pioneer in enzyme kinetics, developed Ping-Pong kinetics and dithiothreitol (DTT). His work utilized heavy atom isotope effects to understand enzyme mechanisms.
Area of Science:
- Biochemistry
- Enzyme Kinetics
Background:
- Professor W. Wallace Cleland was a foundational figure in modern enzyme kinetics.
- He is renowned for developing the Ping-Pong kinetics model and inventing dithiothreitol (DTT).
Discussion:
- Cleland's research significantly advanced the understanding of enzyme-catalyzed reaction mechanisms.
- He pioneered the use of heavy atom isotope effects in mechanistic studies.
Key Insights:
- His contributions include the widely adopted Ping-Pong kinetics model.
- The invention of dithiothreitol (DTT) provided a crucial tool for biochemical research.
Outlook:
- Professor Cleland's legacy continues to influence enzyme kinetics and biochemical research.
- His extensive publication record, particularly in Biochemistry, highlights his lasting impact.
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