Related Experiment Video
Updated: May 5, 2026

Deferred Growth Inhibition Assay to Quantify the Effect of Bacteria-derived Antimicrobials on Competition
Published on: September 3, 2016
Population dynamics of Staphylococcus aureus from Northeastern Nigeria in 2007 and 2012
K O Okon1, A O Shittu2, A A Kudi3
1Department of Medical Laboratory Services,Federal Medical Centre,Makurdi,Nigeria.
Abstract:
The population structure of Staphylococcus aureus is changing globally but the situation regarding dominant clones in sub-Saharan Africa is not clear. We therefore assessed changes in the population structure of clinical S. aureus isolates obtained in 2007 (n = 75) and 2012 (n = 75) from Northeastern Nigeria. A reduction in resistance to penicillin, gentamicin, erythromycin and clindamycin was observed in 2012. A decrease of methicillin resistance rates (13·3% to 8·0%) was associated with the decline of the ST241 MRSA clone. The proportion of Panton-Valentine leukocidin (PVL)-positive isolates also decreased from 65·3% to 44%, and was linked with the emergence of PVL-negative ST601 clone in 2012. The significant decline in antibiotic resistance in the study area is in contrast to the worldwide trend of increasing resistance rates.
Related Concept Videos
Clinical Significance of Antibiotic Resistance
Bacterial Growth Curve
Staphylococcal Skin Infections
Exponential Growth

