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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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Total synthesis of sandresolide B and amphilectolide
Ingrid T Chen1, Irina Baitinger, Lucas Schreyer
1Department of Chemistry and Center of Integrated Protein Science, University of Munich , Butenandtstrasse 5 - 13 (F4.086), 81377 Munich, Germany.
Organic Letters
|December 7, 2013
Abstract:
The total synthesis of the diterpenoids sandresolide B and amphilectolide from a common furan building block is presented. Key steps include palladium-mediated carbonylation, lanthanide catalyzed ring closure, Myers alkylation, intramolecular Friedel-Crafts acylation, photooxygenation, and a Kornblum-DeLaMare rearrangement.
