Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

2.6K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.6K
Plasticity00:58

Plasticity

2.2K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
2.2K
Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
Long-term Potentiation01:35

Long-term Potentiation

51.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
51.6K
Brain Imaging01:14

Brain Imaging

1.0K
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal Tracking of Astrocyte Reactivity During the Development of Chronic Orofacial Neuropathic Pain Using [<sup>18</sup>F]-SMBT-1 Positron-Emission Tomography.

Glia·2026
Same author

Maternal social support as a protective factor in the intergenerational cycle of adversity and pediatric pain: Evidence from the All Our Families cohort study.

Child abuse & neglect·2026
Same author

Game-Based Assessment of Spatial Cognition Across a Wide Age Range.

Behavioral sciences (Basel, Switzerland)·2026
Same author

Understanding pediatric chronic pain through the lens of migration and imposed sociopolitical trauma: a topical review.

Pain·2026
Same author

Infant Abusive Head Trauma Induces Seizures and Cellular Stress in a Pre-Clinical Mouse Model.

Journal of neurotrauma·2026
Same author

Place preference in a female adolescent rat model of neuropathic pain: The effects of cannabidiol and oxycodone on cerebellum cell density.

Psychopharmacology·2026
Same journal

Preface.

Progress in brain research·2025
Same journal

Mindfulness and meditation: Promoting emotional and cognitive health.

Progress in brain research·2025
Same journal

Cognitive stimulation enhancing memory and mental function.

Progress in brain research·2025
Same journal

The science behind non-pharmacological interventions.

Progress in brain research·2025
Same journal

Technology-assisted interventions for neuropsychiatric disorders.

Progress in brain research·2025
Same journal

Ethical consideration in non-pharmacological treatments for neuropsychiatric disorders.

Progress in brain research·2025
See all related articles

Related Experiment Video

Updated: May 5, 2026

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

6.4K

Brain plasticity in the developing brain.

Bryan Kolb1, Richelle Mychasiuk, Arif Muhammad

  • 1Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.

Progress in Brain Research
|December 7, 2013
PubMed
Summary
This summary is machine-generated.

The developing brain is highly adaptable to various experiences and injuries. Injury timing significantly impacts functional outcomes, with earlier damage often leading to poorer results.

Keywords:
brain developmentprefrontal cortexrecovery of functiontypes of plasticity

More Related Videos

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
07:14

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

Published on: January 16, 2026

420
Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
12:47

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

Published on: March 20, 2014

14.6K

Related Experiment Videos

Last Updated: May 5, 2026

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

6.4K
A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
07:14

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

Published on: January 16, 2026

420
Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
12:47

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

Published on: March 20, 2014

14.6K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Neuroplasticity

Background:

  • The developing brain exhibits significant plasticity, adapting to diverse environmental and internal factors.
  • Brain development is a complex process influenced by experiences from early life through adolescence.
  • Understanding these influences is crucial for predicting functional outcomes after brain perturbations.

Purpose of the Study:

  • To review the distinct phases of normal brain development.
  • To examine how various factors influence brain and behavioral development.
  • To propose underlying mechanisms for these developmental effects.

Main Methods:

  • Review of existing literature on brain development and plasticity.
  • Analysis of factors affecting normal and perturbed brain development.
  • Synthesis of proposed mechanisms influencing neurodevelopmental trajectories.

Main Results:

  • Brain plasticity is evident across various developmental stages in response to sensory, social, hormonal, and dietary factors.
  • The timing of injury during development critically affects functional outcomes, with distinct sensitive periods.
  • Pre- and post-injury experiences, along with behavioral assessment age, modulate functional recovery.

Conclusions:

  • Brain development is a dynamic process shaped by a multitude of interacting factors.
  • Age-at-injury is a key determinant of functional outcome, highlighting critical developmental windows.
  • Further research into the mechanisms underlying experience-dependent brain development is warranted.