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Updated: May 5, 2026

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
Published on: February 8, 2020
Mechanisms of plasticity in the developing and adult visual cortex
Mriganka Sur1, Ikue Nagakura, Naiyan Chen
1Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Abstract:
The visual cortex provides powerful evidence for experience-dependent plasticity during development, and for stimulus and reinforcement-dependent plasticity in adulthood. The synaptic and circuit mechanisms underlying such plasticity are being progressively understood. Increasing evidence supports the hypothesis that plasticity in both the developing and adult visual cortex is initiated by a transient reduction of inhibitory drive, and implemented by persistent changes at excitatory synapses. Developmental plasticity may be induced by alterations in the balance of activity from the two eyes and is implemented by a cascade of signals that lead to feedforward and feedback changes at synapses. Adult plasticity is imposed on mature synapses and requires additional neurotransmitter-dependent mechanisms that alter inhibition and subsequently response gain.
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