Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neuronal Communication

Neuronal Communication

Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...

Excitatory and Inhibitory Effects of Neurotransmitters

Excitatory and Inhibitory Effects of Neurotransmitters

When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of specific...

The Role of Ion Channels in Neuronal Computation

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.

Neurochemical Transmission: Sites of Drug Action

Neurochemical Transmission: Sites of Drug Action

Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...

The Synapse

The Synapse

Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Contribution of spike timing to the neural code: from fast to slow timescales.

Biological cybernetics·2026

Same author

Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids.

Nature communications·2026

Same author

Attractor dynamics of a whole-cortex network model predicts emergence and structure of fMRI co-activation patterns in the mouse brain.

PLoS computational biology·2026

Same author

miR126-mediated alteration of vascular integrity in Rett syndrome.

Molecular psychiatry·2026

Same author

Specialized structure of neural population codes in parietal cortex outputs.

Nature neuroscience·2025

Same author

Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing.

eLife·2025

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

Decomposing the modulation of interactions between neuronal populations.

Marco Celotto^1,2, J Samuel Sooter^3,4, Kyle R Jenks¹

¹Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.

Biorxiv : the Preprint Server for Biology

|June 4, 2026

Summary

New Multiplicative Interaction Channels (MICs) reveal how neural population interactions are modulated by third variables like behavior. This method offers a compact way to understand complex neural communication dynamics.

More Related Videos

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Published on: March 8, 2024

Related Experiment Videos

Last Updated: Jun 5, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Published on: March 8, 2024

Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

Understanding neural population interactions is crucial for deciphering brain communication at a cellular level.
Existing methods like communication subspaces capture additive interactions but fail to account for modulatory influences from third variables.

Purpose of the Study:

To extend the communication subspace framework to identify and characterize how third variables modulate neural population interactions.
To introduce Multiplicative Interaction Channels (MICs) for a comprehensive analysis of neural communication.

Main Methods:

Parameterizing modulation as a low-rank tensor within the communication subspace framework.
Deriving MICs through a bilinear perturbation of reduced-rank regression.
Developing a hierarchical fitting pipeline with closed-form decomposition for quantifying modulation effects.

Main Results:

MICs reliably recover modulation in high-dimensional, low-sample data, outperforming existing methods.
Application to prefrontal cortex and visual interneuron data revealed asymmetric modulation of top-down interactions by behavioral state.
Behavioral state reconfigured prefrontal projection patterns interacting with visual interneurons.

Conclusions:

MICs provide an efficient and compact method for characterizing modulatory interactions between neural populations.
This framework enables new investigations into how high-dimensional variables shape neural communication.
MICs advance the understanding of neural population dynamics and brain-wide communication.