Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ascites01:19

Ascites

47
DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...
47
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

440
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
440
Regulation of Food Intake01:30

Regulation of Food Intake

2.8K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.8K
Regulation of Water Intake01:25

Regulation of Water Intake

2.2K
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
2.2K
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

1.9K
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A pilot study on aging-related effects on step performance: The role of muscle quality, size, and strength.

Scientific reports·2026
Same author

Combined effect of metabolic syndrome and cancer on depression.

PloS one·2026
Same author

Platelet Mitochondrial Function, Physical Performance, and Body Composition in Older People Living with HIV: A Preliminary Study.

International journal of molecular sciences·2026
Same author

Spinal cord extracellular matrix hydrogel enhances organoid maturation and functional regeneration after spinal cord injury.

Materials today. Bio·2026
Same author

Smart Glasses for Older Adults With Cognitive Impairment: Explanatory Mixed Methods Study.

JMIR aging·2026
Same author

Effects of High-Intensity Functional Exercise on Cardiorespiratory Fitness and Physical Function in Older Adults With HIV: A Telerehabilitation Randomized Trial.

Open forum infectious diseases·2026
Same journal

Wernicke's Encephalopathy Following Semaglutide Treatment for Obesity: A Systematic PRISMA Review of Case-Based Evidence.

Obesity (Silver Spring, Md.)·2026
Same journal

Appetite Suppression by GLP-1 Receptor Agonists: Role of Delayed Gastric Emptying.

Obesity (Silver Spring, Md.)·2026
Same journal

DXA-Measured Visceral Adipose Tissue and Accelerated Biological Aging in Middle-Aged Adults.

Obesity (Silver Spring, Md.)·2026
Same journal

Real-World Effectiveness of Semaglutide and Tirzepatide Compared With Bariatric Surgery.

Obesity (Silver Spring, Md.)·2026
Same journal

Prospective Association Between Weight Variability and Subsequent Long-Term Weight Loss in the CALERIE Study.

Obesity (Silver Spring, Md.)·2026
Same journal

Dietary Protein Reduction During Isocaloric Conditions Reduces Body Weight in Men With Overweight or Obesity.

Obesity (Silver Spring, Md.)·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Roux-en-Y Gastric Bypass Operation in Rats
07:37

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

23.4K

Decrease of circulating SAA is correlated with reduction of abdominal SAA secretion during weight loss.

Rong-Ze Yang1, Jacob B Blumenthal, Nicole M Glynn

  • 1Division of Endocrinology Diabetes and Nutrition, University of Maryland School of Medicine at Baltimore, Baltimore, Maryland, USA.

Obesity (Silver Spring, Md.)
|December 7, 2013
PubMed
Summary
This summary is machine-generated.

Weight loss reduced serum amyloid A (SAA) by 10%, but no direct correlation was found. Abdominal fat SAA secretion changes, not gluteal, linked to systemic SAA reduction during weight loss.

More Related Videos

Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

6.5K
Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

741

Related Experiment Videos

Last Updated: May 5, 2026

Roux-en-Y Gastric Bypass Operation in Rats
07:37

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

23.4K
Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

6.5K
Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

741

Area of Science:

  • Endocrinology
  • Metabolic Syndrome
  • Obesity Research

Background:

  • Serum amyloid A (SAA) is an acute-phase protein implicated in inflammation.
  • Obesity is associated with chronic low-grade inflammation, potentially involving SAA.
  • Adipose tissue is increasingly recognized as an active endocrine organ secreting various inflammatory mediators.

Purpose of the Study:

  • To investigate the impact of weight loss (WL) alone and combined with aerobic exercise (WL + AEX) on serum SAA levels.
  • To examine adipose tissue SAA secretion from gluteal and abdominal depots before and after WL interventions.
  • To determine the relationship between body weight changes, serum SAA levels, and adipose SAA secretion.

Main Methods:

  • Ninety-six overweight/obese postmenopausal women participated in a 6-month WL or WL + AEX program.
  • Serum SAA levels, body weight, and ex vivo adipose SAA secretion from gluteal and abdominal depots were measured.
  • Statistical analyses were performed to correlate changes in body weight, serum SAA, and adipose SAA secretion.

Main Results:

  • Participants achieved an average of 8% body weight loss, accompanied by a 10% decrease in serum SAA.
  • Serum SAA levels correlated with body weight pre- and post-intervention, but changes did not correlate.
  • Gluteal adipose tissue secreted significantly more SAA than abdominal tissue; however, changes in abdominal SAA secretion correlated with systemic SAA changes during WL.

Conclusions:

  • No linear correlation was observed between the magnitude of systemic SAA reduction and the extent of weight loss.
  • Adipose tissue exhibits depot-specific differences in SAA secretion, with abdominal SAA secretion playing a potential role in systemic SAA reduction during weight loss.