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Updated: May 5, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Synthesis, characterization and antimicrobial activity of certain novel aryl hydrazone pyrazoline-5-ones containing
Maliki Reddy Dastagiri Reddy1, Aluru Raghavendra Guru Prasad, Yadati Narasimha Spoorthy
1Sri Krishnadevaraya University, Anantapur, A.P., India.
Purpose:
The aim of this article is to synthesize, characterize and evaluate the antimicrobial activity of certain novel 3-methyl-5-oxo-4-(phenyl hydrazono)-4,5-dihydro-pyrazol-1-yl]-acetic acid N|-(4-substituted thiazol-2-yl)-hydrazides.
Methods:
The synthesized compounds were characterized by elemental analysis and IR, NMR and mass spectral data. The antimicrobial activity of novel compounds was evaluated by broth dilution method.
Results:
XVe, XVf and XVg have shown better antibacterial activity than other compounds of the series. XVa, XVc, XVd and XVe have shown better antifungal activity than the other compounds of the series.
Conclusion:
All compounds were found to exhibit fair degree of antimicrobial activity.
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