Related Experiment Video
Updated: May 5, 2026
11:27
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
1.8K
Thermal analysis of some antidiabetic pharmaceutical compounds
Ali Kamal Attia1, Magda Mohamed Ibrahim, Mohamed Abdel-Nabi El-Ries
1National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt.
Advanced Pharmaceutical Bulletin
|December 7, 2013
Summary
Thermal analysis techniques like TGA, DTG, and DTA were used to assess the thermal stability and decomposition of antidiabetic drugs. Glimepiride demonstrated the highest thermal stability among the studied compounds.
Area of Science:
- Pharmaceutical Chemistry
- Physical Chemistry
- Materials Science
Background:
- Antidiabetic drugs are crucial for managing diabetes mellitus.
- Understanding the thermal behavior of pharmaceuticals is essential for quality control and stability assessment.
- Pioglitazone hydrochloride, rosiglitazone maleate, glibenclamide, and glimepiride are commonly prescribed antidiabetic medications.
Purpose of the Study:
- To investigate the thermal behavior of pioglitazone hydrochloride (PTZ), rosiglitazone maleate (RGZ), glibenclamide (GBD), and glimepiride (GMP).
- To determine key quality control parameters, including melting points.
- To evaluate and compare the thermal stability of these antidiabetic drugs.
Main Methods:
- Thermogravimetric analysis (TGA)
- Derivative thermogravimetry (DTG)
- Differential thermal analysis (DTA)
- Non-isothermal methods for activation energy determination
Main Results:
- Melting points were determined: PTZ (193.13 °C), RGZ (122.42 °C), GBD (173.75 °C), and GMP (208 °C).
- Melting point values were consistent with official methods, indicating reliable quality control.
- The sequence of thermal stability was established as GMP > GBD > RGZ > PTZ, based on activation energy values.
Conclusions:
- Thermal analysis techniques provide valuable data for the identification and characterization of pharmaceutical compounds.
- The study successfully demonstrated the utility of TGA, DTG, and DTA for comparing the thermal stability of antidiabetic drugs.
- Results offer insights into the thermal decomposition pathways and stability profiles of the investigated medications.
Related Concept Videos
01:27Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
226
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
226
01:06Oral Hypoglycemic Agents: Glinides
1.0K
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
1.0K
01:26Therapeutic Drug Monitoring: Drug Analysis Methods
342
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
342
01:19Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
953
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
953
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
834
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
834
01:26Oral Hypoglycemic Agents: Biguanides and Glitazones
993
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
993