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Study of Thermal Analysis Behavior of Fenbendazole and Rafoxanide
Ali Kamal Attia1, Ahmed Sayed Saad2, Manal Sami Alaraki1
1National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt.
Advanced Pharmaceutical Bulletin
|August 2, 2017
Summary
Thermal analysis of fenbendazole (Fen) and rafoxanide (Raf) confirmed high purity (99.17% and 99.60%). These cost-effective methods are suitable for quality control in laboratories.
Area of Science:
- Analytical Chemistry
- Physical Chemistry
- Computational Chemistry
Background:
- Fenbendazole (Fen) and rafoxanide (Raf) are veterinary anthelmintics.
- Understanding their thermal behavior is crucial for quality control and formulation.
Purpose of the Study:
- To investigate the thermal behavior and purity of fenbendazole and rafoxanide.
- To confirm thermal analysis results using computational methods.
- To evaluate the suitability of thermal analysis for quality control.
Main Methods:
- Thermogravimetric analysis (TGA)
- Derivative thermogravimetry (DTG)
- Differential thermal analysis (DTA)
- Differential scanning calorimetry (DSC)
- Semi-empirical molecular orbital calculations
Main Results:
- Thermal behavior of Fen and Raf was characterized.
- Purity of fenbendazole was determined to be 99.17%.
- Purity of rafoxanide was determined to be 99.60%.
Conclusions:
- Thermal analysis techniques provide accurate and cost-effective quality control parameters.
- The simplicity and sensitivity of these methods make them valuable for laboratory applications.
- Computational methods can augment experimental thermal analysis findings.
