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Related Experiment Video

Updated: May 5, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Persistent erythema multiforme associated with Epstein-Barr virus infection.

N Turnbull1, D Hawkins, M Atkins

  • 1Department of Dermatology, Chelsea and Westminster Hospital, London, UK.

Clinical and Experimental Dermatology
|December 10, 2013
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Summary

Erythema multiforme (EM) is a common skin condition. This study highlights a rare persistent form of EM linked to Epstein-Barr Virus (EBV) infection.

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Area of Science:

  • Dermatology
  • Virology
  • Immunology

Background:

  • Erythema multiforme (EM) is typically self-limiting, with recurrent forms often linked to herpes simplex virus.
  • Persistent EM is rare, characterized by prolonged, atypical inflammatory lesions.
  • Potential associations include viral infections, inflammatory bowel disease, and malignancy.

Observation:

  • This case report details a patient with persistent Erythema multiforme.
  • The persistent EM was found to be associated with Epstein-Barr Virus (EBV) infection.
  • This association is less common than typical EM triggers.

Findings:

  • Persistent Erythema multiforme can be associated with Epstein-Barr Virus (EBV).
  • This case adds to the limited literature on persistent EM and its potential triggers.
  • The protracted and atypical nature of persistent EM warrants further investigation into underlying causes.

Implications:

  • Understanding the link between EBV and persistent EM may guide diagnostic approaches.
  • This finding could inform management strategies for rare, persistent EM cases.
  • Further research is needed to elucidate the mechanisms linking EBV to persistent EM.