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Psoriasis in pregnancy: a review (II)
V Ruiz1, E Manubens1, L Puig1
1Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
Actas Dermo-Sifiliograficas
|December 10, 2013
Summary
Limited data exists on biologic drug safety for pregnant women with psoriasis. While current evidence suggests potential safety, more research is needed to confirm effects on embryonic and fetal development.
Area of Science:
- Dermatology and Immunology
- Reproductive Medicine
Background:
- Psoriasis treatment during pregnancy presents challenges due to ethical constraints on clinical trials.
- Existing data on biologic use in gestation is limited, primarily from observational studies in other rheumatic conditions.
Purpose of the Study:
- To review the accumulated experience and available evidence regarding the use of biologic therapy in pregnant women with psoriasis.
- To assess the potential safety and effects of biologics on embryonic and fetal development in this population.
Main Methods:
- Comprehensive literature review focusing on observational studies and case reports.
- Analysis of data primarily derived from the management of rheumatic diseases during pregnancy.
- Assessment of the growing use of biologics in psoriasis management during gestation.
Main Results:
- Scientific evidence defining the precise effects of biologics on embryonic and fetal development in pregnant psoriasis patients is scarce.
- Published data, mainly from retrospective and observational studies, suggests potential safety of biologic therapy during pregnancy.
- Experience with biologics specifically in pregnant women with psoriasis remains very limited.
Conclusions:
- While literature suggests biologic therapy may be safe during pregnancy for psoriasis, definitive conclusions cannot be drawn due to limited evidence.
- Further research, including well-designed studies, is necessary to establish the safety profile and developmental effects of biologics in pregnant psoriasis patients.
- The use of biologic agents in psoriasis during pregnancy is increasing, highlighting the need for robust safety data.
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