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Effects of iron therapy on blood lead concentrations in infants

Sangkyu Park1, Chang Sun Sim2, Heun Lee2

  • 1Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|December 10, 2013
PubMed

Insights

Iron deficiency in infants is linked to higher blood lead levels. Iron supplementation significantly reduced blood lead concentrations in these infants, highlighting the importance of iron status for lead exposure.

Area of Science:

  • Pediatric Nutrition
  • Environmental Health
  • Toxicology

Background:

  • Iron deficiency is common in infants and may affect lead absorption.
  • Elevated blood lead concentrations pose significant health risks to children.

Purpose of the Study:

  • To investigate the relationship between iron deficiency and blood lead concentration in infants.
  • To assess the impact of iron supplementation on blood lead levels in iron-deficient infants.

Main Methods:

  • Blood lead and serum ferritin levels were measured in iron-deficient and control infants (aged 6-24 months).
  • Iron-deficient infants received iron supplementation; blood lead levels were re-measured after ferritin normalization.

Main Results:

  • Iron-deficient infants had higher geometric mean blood lead concentrations than controls.
  • Iron therapy significantly decreased blood lead levels and increased hemoglobin and ferritin levels.

Conclusions:

  • Iron deficiency is associated with elevated blood lead concentrations in infants.
  • Iron supplementation can effectively reduce blood lead levels in iron-deficient infants.

Keywords:
AnemiaDeficiencyIronLead

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