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Zoledronate-pulsed dendritic cell-based anticancer vaccines

Takashi Kamigaki1, Masashi Takahara, Ryuji Maekawa

  • 1Seta Clinic; Tokyo, Japan.

Oncoimmunology
|December 10, 2013
PubMed

The addition of zoledronate to tumor-associated antigen (TAA)-loaded dendritic cells (DCs) promotes the activation of interferon γ-secreting Vγ9 γδ T cells, in turn eliciting TAA-specific CD8+ T-cell responses. Immunological responses induced by zoledronate-pulsed DC-based vaccines have been associated with therapeutic effects in clinical trials.

Keywords:
Wilms’ tumor 1dendritic cellelectroporationintratumoral injectiontumor-associated antigen-derived peptidezoledronate

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