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Total synthesis of the marine alkaloid Mansouramycin D
K S Prakash1, Rajagopal Nagarajan
1School of Chemistry, University of Hyderabad , Hyderabad-500 046, India.
Organic Letters
|December 11, 2013
Abstract:
Mansouramycin D, a cytotoxic alkaloid was isolated from a marine Streptomyces sp. in 2009. The first, simple, and concise route to the total synthesis of Mansouramycin D is reported. The core structure of the isoquinoline ring has been constructed from iminoannulation of 2-alkynylbenzaldehyde followed by oxidation/deprotection and oxidative amination via a three-step sequence from easily accessible starting materials.
