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Autonomic dysfunction in multiple sclerosis.

Ivan Adamec1, Mario Habek

  • 1University Hospital Center Zagreb, Department of Neurology, Refferal Center for Demyelinating Diseases of the Central Nervous System, Zagreb, Croatia.

Clinical Neurology and Neurosurgery
|December 11, 2013
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) damages the autonomic nervous system, leading to autonomic dysfunction (AD). This review covers the symptoms and signs of AD in MS patients, often overlooked despite its impact.

Keywords:
Autonomic dysfunctionCardiovascular dysfunctionMultiple sclerosis

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Area of Science:

  • Neurology
  • Neuroscience

Background:

  • Multiple sclerosis (MS) is a primary cause of neurological disability in young adults.
  • MS pathophysiology involves lesions disseminating in space and time, frequently affecting the autonomic nervous system.
  • Autonomic dysfunction (AD) in MS results from damage to brainstem and medullar autonomic regulatory centers.

Purpose of the Study:

  • To provide a concise review of the symptoms and signs of autonomic dysfunction in multiple sclerosis patients.
  • To highlight the impact of AD on quality of life in MS, which is often underestimated.

Main Methods:

  • Literature review of studies on autonomic dysfunction in multiple sclerosis.
  • Synthesis of reported symptoms and signs of AD based on lesion locations.

Main Results:

  • Autonomic dysfunction is a common complication of MS, with prevalence increasing with disease duration.
  • Lesions in specific brainstem and medullar regions are implicated in MS-related AD.
  • Reported frequencies of AD in MS vary, but its impact on quality of life is significant.

Conclusions:

  • Autonomic dysfunction is an integral, though often overlooked, component of multiple sclerosis.
  • Understanding the diverse symptoms and signs of AD is crucial for managing MS patients effectively.
  • Further research is needed to clarify the exact prevalence and impact of AD in MS.