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Localization, Identification, and Excision of Murine Adipose Depots
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Adipose tissue, diet and aging.

Mauro Zamboni1, Andrea P Rossi1, Francesco Fantin1

  • 1Department of Medicine, Geriatric Medicine, University of Verona, Italy.

Mechanisms of Ageing and Development
|December 11, 2013
PubMed
Summary
This summary is machine-generated.

Aging increases body fat and inflammation in adipose tissue (AT), impacting elderly health. More research is needed on how dietary patterns affect AT changes in older adults.

Keywords:
AdipokynesAdipose tissueAgingInflammation

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Area of Science:

  • Gerontology
  • Metabolism
  • Immunology

Background:

  • Aging is associated with increased body fat, visceral adipose tissue (AT), and ectopic fat deposition, contributing to poor health outcomes in the elderly.
  • Adipose tissue (AT) in older individuals often exhibits heightened inflammation, potentially driving inflammaging and affecting AT function.
  • Aging impacts AT by altering adipokine profiles, reducing preadipocyte function, and increasing macrophage infiltration.

Purpose of the Study:

  • To investigate the relationship between dietary patterns and age-related changes in adipose tissue (AT) structure, distribution, and function.
  • To explore the role of nutrients and dietary patterns in modulating AT inflammation and function in the elderly.
  • To address the sparse and controversial evidence regarding diet and AT in older populations.

Main Methods:

  • Review of existing literature on aging, adipose tissue (AT) function, inflammation, and dietary patterns.
  • Analysis of studies examining nutrient-specific effects on AT.
  • Consideration of the complex interplay of foods and nutrients within dietary patterns.

Main Results:

  • Aging significantly alters AT composition and function, characterized by increased fat mass, visceral and ectopic fat, and inflammation.
  • Specific nutrients and dietary patterns may influence AT inflammation and function, though evidence in older adults is limited and conflicting.
  • The precise initiating events of AT inflammation during aging remain unclear.

Conclusions:

  • Dietary patterns play a crucial role in modulating age-related changes in adipose tissue (AT) structure, distribution, and function.
  • Further research is essential to elucidate the impact of various dietary patterns on AT health in the elderly.
  • Understanding these interactions is key to developing targeted nutritional strategies for healthy aging.