Related Experiment Video

Updated: May 5, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

11.6K

[Domiciliary parenteral antibiotic therapy: a prospective analysis of the last 12 years]

M J Peláez Cantero1, A Madrid Rodríguez1, A L Urda Cardona1

  • 1Unidad de Gestión Clínica de Pediatría, Hospital Carlos Haya, Málaga, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|December 11, 2013
PubMed

Insights

Outpatient parenteral antibiotic therapy (OPAT) provided by Hospital at Home Units (HHU) is a safe and effective treatment for pediatric patients. This 12-year study shows a 90.2% success rate for home-based antimicrobial treatments.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Stewardship
  • Home Healthcare Models

Context:

  • Parenteral antibiotic therapy traditionally requires hospitalization.
  • Hospital at Home Units (HHU) are increasingly managing pediatric patients requiring intravenous antibiotics.
  • This study evaluates a 12-year experience with home-based antimicrobial therapy.

Purpose:

  • To describe the experience of a pediatric Hospital at Home Unit (HHU) in providing outpatient parenteral antibiotic therapy (OPAT) over 12 years.
  • To analyze the types of infections treated, antibiotics used, and outcomes of pediatric OPAT.
  • To assess the safety and efficacy of home-based antimicrobial treatment in children.

Summary:

  • A 12-year prospective study of 163 pediatric patients receiving OPAT via HHU.
  • Respiratory tract infections were the most common indication (76%).
  • Amikacin was frequently used, with 96.6% of treatments administered intravenously. Successful at-home treatment was achieved in 90.2% of cases, with catheter-associated complications being more frequent than drug-associated ones.

Impact:

  • OPAT through HHUs demonstrates a high success rate (90.2%) in pediatric patients.
  • Home-based parenteral antibiotic therapy is a safe and viable alternative to hospitalization for various pediatric conditions.
  • This model of care can potentially reduce healthcare costs and improve patient quality of life.
Abstract

Keywords:
Home therapyInfecciónIntravenosoOutpatient parenteral antimicrobial therapyPediatric infectionsTratamiento antimicrobiano domiciliario intravenosoTratamiento antimicrobiano parenteral ambulatorioTratamiento domiciliario

More Related Videos

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump06:08

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump

Published on: March 11, 2017

10.0K
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

18.4K

Related Concept Videos

Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
3.7K
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
423
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
386
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
208
Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
2.0K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
842