[Advances in the treatment of secondary osteoporosis]
R Galindo Zavala1, E Núñez Cuadros1, G Díaz Cordovés-Rego1
1Sección de Reumatología Infantil, Unidad de Gestión Clínica de Pediatría, Hospital Regional Universitario de Málaga, Málaga, España.
Insights
Childhood secondary osteoporosis management involves non-pharmacological strategies and bisphosphonates. Further research is needed to clarify the effectiveness and safety of these treatments in children.
Area of Science:
- Pediatric Endocrinology
- Bone Metabolism
- Pharmacology
Background:
- Osteoporosis is increasingly recognized in children due to longer life expectancy for those with chronic diseases.
- Non-pharmacological interventions like adequate nutrition, sun exposure, and weight-bearing exercise can improve bone health.
- The roles of Vitamin D and calcium supplements are not fully established for increasing bone mass in children.
Purpose of the Study:
- To analyze the scientific evidence on the effectiveness of therapeutic alternatives for childhood secondary osteoporosis.
- To evaluate the safety of these treatments in pediatric patients.
- To review current pharmacological options and their limitations.
Main Methods:
- Systematic review of scientific literature on childhood secondary osteoporosis treatments.
- Analysis of evidence regarding non-pharmacological interventions.
- Evaluation of clinical trial data for bisphosphonate efficacy and safety.
Main Results:
- Non-pharmacological measures are crucial for improving pediatric bone health.
- Bisphosphonates are the primary pharmacological treatment for infantile secondary osteoporosis.
- More research is required on bisphosphonate indications, dosage, and long-term effects.
Conclusions:
- Optimizing non-pharmacological strategies is essential for managing childhood secondary osteoporosis.
- Bisphosphonates offer a therapeutic option but require further investigation for optimal use in children.
- Comprehensive understanding of treatment efficacy and safety is critical for pediatric bone health.
Abstract:
Osteoporosis is being increasingly recognised in paediatric practice as a consequence of the increasing life expectancy of children who suffer from chronic diseases and other factors. There are many non-pharmacological measures that can improve children' bone health, for example, avoiding inflammatory activity and osteotoxic treatments; increasing sun exposure and weight-bearing exercise, and maintaining an adequate nutritional status. Vitamin D and calcium supplements have been proposed as a measure to increase bone mass, but their effect and therapeutic indications are not completely clear. On the other hand, bisphosphonates are currently the only pharmacological alternative for the patients with infantile secondary osteoporosis. However, more studies are required on the therapeutic indications, posology, and long term secondary effects of biphosphonates. The aim of this article is to analyze the scientific evidence of the effectiveness of the therapeutic alternatives for childhood secondary osteoporosis and their safety in children.
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