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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Childhood cancers: what is a possible role of infectious agents?
Kenneth Alibek, Assel Mussabekova, Ainur Kakpenova1
1Nazarbayev University Research and Innovation System, 53 Kabanbay Batyr Avenue, Astana 010000, Kazakhstan. akakpenova@nu.edu.kz.
Abstract:
The etiology of childhood cancers has been studied for more than 40 years. However, most if not all cancers occurring in children are attributed to unknown causes. This review is focused on the role of infections in cancer development and progression in children. The main infectious agents include human herpesviruses, polyoma viruses, and human papilloma viruses. It is known that infections can lead to carcinogenesis through various mechanisms, and most likely act in addition to genetic and environmental factors. Given the importance of the infectious etiology of childhood cancers, clinical implications and possible prevention strategies are discussed.
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