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Updated: May 5, 2026
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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
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Gastric eosinophilia--clinical and morphological correlations
Adriana Bold1, Diana Maria Traşă, Lavinia Olar
1Department of Histology, University of Medicine and Pharmacy of Craiova, Romania; garo2963@yahoo.com.
Summary
Eosinophils, immune cells in the gut, are present in over a third of chronic gastritis cases. They are more common in severe gastritis and Helicobacter pylori infections, suggesting a role in these conditions.
Area of Science:
- Gastroenterology
- Immunology
- Pathology
Background:
- Eosinophils in the gastrointestinal tract are key immune cells involved in pathogen defense and epithelial homeostasis.
- Their specific role in chronic gastritis, particularly its subtypes and associations, remains less understood.
Purpose of the Study:
- To investigate the presence and prevalence of eosinophils in the gastric mucosa of patients with chronic gastritis.
- To determine if eosinophil presence correlates with specific types of chronic gastritis, such as atrophic gastritis with intestinal metaplasia and Helicobacter pylori infection.
Main Methods:
- Histopathological examination of gastric biopsy samples.
- Identification and quantification of eosinophils in the gastric mucosa (lamina propria).
- Correlation analysis of eosinophil counts with gastritis classification and H. pylori status.
Main Results:
- Eosinophils were identified in the gastric mucosa of over 34% of chronic gastritis patients.
- Higher eosinophil counts were observed in cases of atrophic gastritis with intestinal metaplasia.
- Over 65% of chronic gastritis cases associated with Helicobacter pylori infection showed eosinophil presence.
Conclusions:
- Eosinophils are frequently present in the gastric mucosa during chronic gastritis.
- Eosinophil infiltration is associated with more severe forms of gastritis, including atrophic gastritis with intestinal metaplasia and H. pylori infection.
- These findings suggest eosinophils play a role in the inflammatory processes of chronic gastritis.
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