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Can Admission Neutrophil to Lymphocyte Ratio Predict Infarct-Related Artery Patency in ST-Segment Elevation
Mehmet Doğan1, Ahmet Akyel2, Murat Bilgin2
1Department of Cardiology, Ministry of Health Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey drmehmetdogan@yahoo.com.
Insights
The neutrophil to lymphocyte ratio (NLR) and glucose levels were higher in patients with occluded infarct-related arteries (IRA) in ST-segment elevation myocardial infarction (STEMI). Admission NLR predicts IRA patency, offering a cost-effective diagnostic tool.
Area of Science:
- Cardiology
- Hematology
- Biomarkers
Background:
- ST-segment elevation myocardial infarction (STEMI) requires prompt restoration of infarct-related artery (IRA) patency.
- Predictive markers for IRA patency are crucial for patient management and outcomes.
Purpose of the Study:
- To investigate the association between neutrophil to lymphocyte ratio (NLR) and IRA patency in STEMI patients.
- To determine if NLR and glucose levels can predict IRA patency.
Main Methods:
- Retrospective analysis of 349 STEMI patients.
- Evaluation of IRA patency using thrombolysis in myocardial infarction (TIMI) flow grade.
- Comparison of baseline characteristics, including NLR and glucose levels, between occluded and patent IRA groups.
Main Results:
- Patients with occluded IRA had significantly higher admission NLR (4.4 ± 4.1 vs 1.9 ± 1.1, P < .001) and glucose levels (171.3 ± 78.0 vs 144.7 ± 49.7, P = .022).
- Regression analysis identified admission NLR and plasma glucose as independent predictors of IRA patency.
- A higher proportion of patients had occluded IRA (293 vs 56).
Conclusions:
- Admission NLR and glucose levels are elevated in STEMI patients with occluded IRA.
- NLR and glucose levels are independent predictors of IRA patency.
- The readily available hemogram test, measuring NLR, can serve as a practical predictor of IRA patency in clinical practice.
Objectives:
In this study, we aimed to investigate the relationship between neutrophil to lymphocyte ratio (NLR) and infarct-related artery (IRA) patency in patients with ST-segment elevation myocardial infarction (STEMI).
Methods:
A total of 349 patients with STEMI were recruited to this retrospective study. Baseline characteristics were reviewed. Patency of IRA was evaluated by thrombolysis in myocardial infarction flow grade.
Results:
Of all patients, 293 patients formed the occluded IRA group and 56 patients formed the patent IRA group. The NLR was significantly higher in occluded IRA group (4.4 ± 4.1 vs 1.9 ± 1.1, P < .001). Glucose levels were also higher in occluded IRA group (171.3 ± 78.0 vs 144.7 ± 49.7, P = .022). Regression analysis demonstrated admission NLR and plasma glucose levels as independent predictors of IRA patency.
Conclusion:
In this study, we found that admission NLR and glucose levels were higher in patients with occluded IRA than in patients with STEMI. We also found that NLR and glucose levels were independent predictors of IRA patency. Because hemogram is a cheap, fast, and widely available test, it can be used in daily practice as a predictor of IRA patency.
