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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Related Experiment Video

Updated: May 5, 2026

Clinical Imaging of Microwave Mammography
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Molecular breast imaging with gamma emitters.

O Schillaci1, A Spanu, R Danieli

  • 1Department of Biomedicine and Prevention Tor Vergata University, Rome Italy - orazio.schillaci@uniroma2.it.

The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR), [And] Section of the Society Of
|December 11, 2013
PubMed
Summary

Early detection of breast cancer (BC) recurrence is crucial. Molecular breast imaging (MBI) shows promise for diagnosing recurrence, especially with advanced imaging technologies, offering an alternative to conventional methods affected by scar tissue.

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Area of Science:

  • Nuclear medicine
  • Oncology
  • Radiology

Background:

  • Local recurrence remains a significant challenge in breast cancer (BC) management despite therapeutic advancements.
  • Conventional imaging methods struggle to differentiate recurrence from post-therapy scar tissue.

Purpose of the Study:

  • To review the applications of 99mTc-sestamibi and 99mTc-tetrofosmin in molecular breast imaging (MBI) for diagnosing local BC recurrence.
  • To discuss the potential of advanced MBI technologies in improving recurrence detection rates.

Main Methods:

  • Review of studies utilizing 99mTc-sestamibi and 99mTc-tetrofosmin for MBI in BC recurrence.
  • Evaluation of conventional gamma-cameras, SPECT/CT, and dedicated breast cameras for MBI.

Main Results:

  • MBI is not affected by post-therapy morphologic changes, making it useful for BC recurrence diagnosis.
  • Low sensitivity of conventional MBI for small BC recurrences is a limitation.
  • Hybrid SPECT/CT and high-resolution breast cameras enhance detection of sub-centimetric lesions.

Conclusions:

  • Widespread availability of dedicated MBI cameras is likely necessary for clinical acceptance.
  • MBI holds potential as a complementary diagnostic tool for BC recurrence.
  • MBI may also play a role in monitoring neoadjuvant chemotherapy response.