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Updated: May 5, 2026
08:34
Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
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Adiponectin as a tissue regenerating hormone: more than a metabolic function.
Tania Fiaschi1, Francesca Magherini, Tania Gamberi
1Dipartimento di Scienze Biomediche, Sperimentali e Cliniche, Universita' degli Studi di Firenze, Viale Morgagni 50, 50134, Florence, Italy, tania.fiaschi@unifi.it.
Cellular and Molecular Life Sciences : CMLS
|December 11, 2013
Summary
Adiponectin, a key metabolic hormone, also significantly aids tissue regeneration, particularly in skeletal muscle. This review highlights its role in promoting muscle stem cell proliferation and repair, extending beyond its known metabolic functions.
Area of Science:
- Endocrinology
- Molecular Biology
- Regenerative Medicine
Background:
- Adiponectin is a crucial adipokine regulating glucose homeostasis and inflammation.
- It exists in full-length, complexed, and globular forms.
- Emerging evidence suggests pleiotropic roles beyond metabolism.
Purpose of the Study:
- To review the role of adiponectin in tissue regeneration.
- To focus on adiponectin's involvement in skeletal muscle regeneration.
Main Methods:
- Literature review of studies on adiponectin and tissue regeneration.
- Analysis of adiponectin's effects on muscle stem cells and precursors.
Main Results:
- Adiponectin deficiency impairs tissue renewal mechanisms.
- Globular adiponectin enhances proliferation, migration, and myogenic properties of muscle stem cells (satellite cells) and mesoangioblasts.
- Skeletal muscle may locally produce globular adiponectin in inflammatory conditions.
Conclusions:
- Adiponectin possesses a significant, previously underappreciated role in tissue regeneration.
- Its functions in skeletal muscle repair complement its established metabolic actions.
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