Related Experiment Video
Updated: May 16, 2026

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts
Published on: April 13, 2022
Amino acid metabolism at the senescence-cancer interface
Giulia Lori1, Caterina Mancini1, Erica Pranzini2
1Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 50, Florence 50134, Italy.
Abstract:
Amino acid (AA) metabolism plays a fundamental role in the regulation of cellular senescence. Through profound AA metabolic reprogramming, senescent stromal cells can sustain tumor progression, metastatic dissemination, and the establishment of an immunoevasive microenvironment. Conversely, alterations in AA availability within the tumor microenvironment can enforce tumor-suppressive senescence in malignant cells. In this review, we discuss how senescence-driven rewiring of AA metabolism shapes tumor-stroma interactions and immune responses. We propose that AA-targeted interventions may represent an effective therapeutic strategy to simultaneously mitigate the detrimental effects of stromal senescence while inducing tumor-suppressive senescence in cancer cells.
Related Concept Videos
Replicative Cell Senescence
Replicative Cell Senescence
Amino Acid Biosynthetic Pathways
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Mitochondria

