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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Correction: Rao et al. Ensemble Deep-Learning-Based Prognostic and Prediction for Recurrence of Sporadic Odontogenic Keratocysts on Hematoxylin and Eosin Stained Pathological Images of Incisional Biopsies. <i>J. Pers. Med.</i> 2022, <i>12</i>, 1220.

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Related Experiment Video

Updated: May 5, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

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A foreigner in squamous cell carcinoma!

Shankargouda Patil1, Roopa S Rao, B S Ganavi

  • 1Department of Oral & Maxillofacial Pathology, M S Ramaiah Dental College & Hospital, Bangalore, Karnataka, India.

Journal of International Oral Health : JIOH
|December 11, 2013
PubMed
Summary
This summary is machine-generated.

Foreign body giant cells (FBGCs) can mimic aggressive oral cancer features. This study clarifies their appearance, pathogenesis, and significance in squamous cell carcinoma (SCC) to aid pathologists.

Keywords:
Squamous cell carcinomaforeign body giant cellskeratin pearls

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Area of Science:

  • Oral pathology
  • Oncology
  • Immunology

Background:

  • Squamous cell carcinoma (SCC) is the most common oral cancer with diverse histopathological presentations.
  • Well-differentiated SCC features keratinizing islands and inflammatory responses.
  • Keratin debris can elicit a foreign body giant cell (FBGC) reaction.

Purpose of the Study:

  • To elucidate the role and characteristics of FBGCs in oral SCC.
  • To differentiate FBGCs from neoplastic giant cells in SCC.
  • To enhance diagnostic accuracy in oral squamous cell carcinoma.

Main Methods:

  • Case study review.
  • Histopathological analysis of oral SCC with FBGCs.
  • Literature review on FBGCs and oral SCC.

Main Results:

  • Identified FBGCs in oral SCC, triggered by keratinization.
  • Observed that FBGCs can be mistaken for pleomorphic giant cells, potentially misdiagnosing SCC aggressiveness.
  • Highlighted the importance of distinguishing FBGCs from true neoplastic giant cells.

Conclusions:

  • FBGCs are a notable reactive phenomenon in oral SCC.
  • Accurate identification of FBGCs is crucial to avoid misinterpretation of SCC grade and prognosis.
  • Understanding FBGCs improves diagnostic precision in oral cancer pathology.