Related Experiment Video
Updated: May 5, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Changes of plasma B-type natriuretic peptide levels after high-pressure post-dilation following coronary stent
Gang-Yong Wu1, Gang-Jun Zong, Jing-Kai Chen
1Department of Cardiology, No. 101 Hospital of PLA, Wuxi, Jiangsu Province, China.
Insights
High-pressure post-dilation after coronary stenting significantly increases B-type natriuretic peptide (BNP) levels. This intervention also elevates troponin I and C-reactive protein, suggesting potential myocardial injury and inflammation.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Percutaneous coronary intervention (PCI) with stent deployment is a common treatment for coronary artery disease.
- The role of high-pressure post-dilation in influencing cardiac biomarkers requires further investigation.
Purpose of the Study:
- To evaluate the impact of high-pressure post-dilation on plasma B-type natriuretic peptide (BNP) levels following coronary stent deployment.
- To compare changes in BNP, troponin I (TnI), creatine kinase-MB (CK-MB), and high-sensitivity C-reactive protein (hs-CRP) between conventional and high-pressure post-dilation groups.
Main Methods:
- A study involving 173 patients undergoing PCI for left anterior descending artery stenosis.
- Patients were randomized into two groups: conventional balloon dilation and high-pressure post-dilation.
- Plasma BNP, TnI, CK-MB, and serum hs-CRP levels were measured before and 24 hours after the procedure.
Main Results:
- No significant differences in baseline characteristics or pre-procedural markers between groups.
- The conventional group showed a significant decrease in post-procedural BNP levels (P=0.001).
- The high-pressure post-dilation group exhibited significant increases in post-procedural BNP (P<0.0001), TnI (P<0.0001), and hs-CRP (P<0.0001) compared to pre-procedural levels.
- Post-procedural BNP, TnI, and hs-CRP levels were significantly higher in the high-pressure post-dilation group compared to the conventional group (all P<0.0001).
Conclusions:
- High-pressure post-dilation following coronary stent deployment leads to a significant elevation in plasma BNP levels.
- This increase in BNP, along with elevated TnI and hs-CRP, suggests potential links to altered myocardial perfusion, increased myocardial injury, and heightened inflammation.
Objective:
To evaluate the changes of plasma B-type natriuretic peptide(BNP) levels after high-pressure post-dilation following coronary stent deployment.
Methods:
A total of 173 patients undergoing percutaneous coronary intervention for the left anterior descending artery were enrolled into the study. All patients were divided into two groups: the conventional group and the post-dilation group. The plasma BNP, troponin I(TnI), myocardial band isoenzyme of creatine kinase(CK-MB) levels and the serum high sensitive C-reactive protein(hs-CRP) levels immediately before and 24 hours after the interventional procedures were compared between the two groups.
Results:
There were no significant differences between the two groups in terms of clinical features, clinical and biochemical parameters, stent parameters, pre-procedural plasma BNP and TnI levels, pre-procedural serum hs-CRP levels, as well as pre- and post-procedural CK-MB levels (all P>0.05). In the conventional group, post-procedural plasma BNP levels were significantly reduced when compared with the pre-procedural levels, median(25th,75th) were 32.5 ng/L(15.0,52.4) vs. 37.7 ng/L(18.2,67.3), P = 0.001. In the post-dilation group, post-procedural plasma BNP levels were significantly increased when compared with the pre-procedural levels, median(25th,75th) were 53.5 ng/L(29.6,82.8) vs. 44.2 ng/L(17.15,70.7), P<0.0001. Post-procedural plasma TnI levels were also significantly increased when compared with the pre-procedural levels in both groups, median(25th,75th) were 0.02 ng/L(0.01,0.08) vs. 0.01 ng/L(0.01,0.01), 0.05 ng/L(0.01,0.35) vs. 0.01 ng/L(0.01,0.01), respectively, P<0.0001, so were the serum hs-CRP levels, median(25th,75th) were 3.3 mg/L(2.4,4.7) vs. 2.2 mg/L(1.4,3.3), 4.2 mg/L(3.175,5.825) vs. 2.3 mg/L(1.45,3.6), respectively, P<0.0001. Post-procedural plasma BNP, TnI and serum hs-CRP levels in the post-dilation group were significantly higher than those in the conventional group(all P<0.0001).
Conclusion:
High-pressure post-dilation following coronary stent deployment resulted in a significant increase of plasma BNP levels, as well as plasma TnI levels and serum hs-CRP levels, which may be related to myocardial perfusion, more myocardial injury and more inflammation.
More Related Videos
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:29Heart Failure II: Pathophysiology
01:17Hormonal Regulation of Blood Pressure
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...