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Related Experiment Videos

Chronic antithrombogenic biomaterials screen.

M Lubin, T Nappholz, C W Miller

    Pacing and Clinical Electrophysiology : PACE
    |November 1, 1986
    PubMed
    Summary
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    New passivation techniques for cardiac implantable sensors show promise in reducing tissue buildup. Further research is needed to understand their long-term performance and potential interactions with mineralization.

    Area of Science:

    • Biomaterials Science
    • Medical Device Engineering
    • Cardiovascular Research

    Background:

    • Chronic implantable sensors for cardiac devices face challenges due to sensor technology limitations and the absence of antithrombogenic surface passivation.
    • Effective passivation is crucial for long-term performance and biocompatibility of implanted medical devices.

    Purpose of the Study:

    • To evaluate the thrombogenic character and tissue response of six different passivation types on dummy pacing leads.
    • To assess the general performance of these passivations in maintaining optically clear windows for biological observation.

    Main Methods:

    • Dummy pacing leads with six passivation types were implanted in 36 dogs for 17 weeks.
    • Aseptic surgical procedures and regular blood work-up were employed.

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  • Explanted devices were analyzed for tissue accumulation, and advanced microscopy techniques (SEM, EDAX) were used on select samples.

    • Main Results:

    • Devices were categorized into two groups based on the percentage of surface area covered by tissue accumulation, with three passivation types in each group.
    • Substrate surface finish, topography, and mineralization phenomena were identified as significant factors.
    • Preliminary evidence suggests a potential link between antithrombogenic properties and enhanced mineralization or degradation.

    Conclusions:

    • Passivation strategies significantly influence tissue response and performance of cardiac implantable sensors.
    • Surface characteristics like finish and topography are critical for device biocompatibility.
    • Further investigation is required to elucidate the relationship between antithrombogenic properties, mineralization, and long-term device stability.