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High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET
Muhammad Rashed Javed1, Supin Chen, Jack Lei
1Department of Molecular Imaging and Medical Pharmacology, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA. pkeng@mednet.ucla.edu.
Chemical Communications (Cambridge, England)
|December 12, 2013
Abstract:
[(18)F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol(-1) (20 Ci μmol(-1)) (n = 4). Specific activity was ~2-fold higher than [(18)F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.
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