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Updated: May 5, 2026

Detecting Amyloid-β Accumulation via Immunofluorescent Staining in a Mouse Model of Alzheimer's Disease
Published on: April 19, 2021
A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's
Masha G Savelieff1, Yuzhong Liu, Russell R P Senthamarai
1Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Abstract:
Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-β (Aβ) over Zn(II)-Aβ.
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