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A feasibility study on femtosecond laser thrombolysis
Johannes Bidinger1, Roland Ackermann, Giorgio Cattaneo
11 Institute of Applied Physics, Abbe Center of Photonics, Friedrich-Schiller-Universität Jena , Jena, Germany .
Photomedicine and Laser Surgery
|December 17, 2013
Summary
Femtosecond laser thrombolysis shows promise for dissolving blood clots. The 800 nm wavelength is preferred for its higher threshold difference, aiding in vascular wall protection.
Area of Science:
- Medical Engineering
- Biomedical Optics
- Laser Surgery
Background:
- Femtosecond laser surgery offers minimal side effects due to low pulse energies.
- Advancements in laser sources and fiber technology enable catheter-based treatments.
Purpose of the Study:
- To investigate the feasibility of femtosecond laser thrombolysis.
- To evaluate laser ablation parameters for thrombi and blood vessels.
Main Methods:
- Utilized two femtosecond laser systems (800 nm, 1030 nm) and a 3D scanner.
- Performed in vitro experiments on porcine thrombi and blood vessels.
- Determined ablation thresholds and rates, monitoring with a fiber spectrometer.
Main Results:
- Achieved thrombus ablation rates of approximately 0.04 mm³/sec.
- Observed significant differences in ablation thresholds between thrombi and blood vessels at both wavelengths (800 nm: 3x, 1030 nm: 1.5x).
- Detected second harmonic generation in blood vessels but not thrombi at 5 mm distance.
Conclusions:
- Femtosecond laser thrombolysis can effectively destroy thrombus volumes within a practical timeframe.
- The 800 nm wavelength is recommended due to a greater threshold difference, enhancing safety.
- Second harmonic generation detection offers potential for real-time vascular wall protection.
