Related Experiment Video
Updated: May 4, 2026

Murine Model of CD40-activation of B cells
Published on: March 5, 2010
Murine b7-h3 is a co-stimulatory molecule for T cell activation
Ruhong Yan1, Shun Yang, Aiping Gu
11 Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University , Suzhou, China .
Abstract:
The B7 family member B7-H3 (CD276) plays a key role during an immune response but its function remains controversial. In this study, we found that murine B7-H3 up-regulated the proliferation and cytokine production of T cells. Our study suggested that there was no interaction of murine B7-H3 with a triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2). Further studies demonstrated that mouse B7-H3 specifically bound to T cells and its receptor was not murine TLT-2. Moreover, murine B7-H3 was a positive co-stimulatory molecule in the regulation of T cell-mediated immune responses.
Related Concept Videos
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

