Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

11.7K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
11.7K
Mitochondrial Membranes01:45

Mitochondrial Membranes

2.1K
2.1K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

3.5K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.5K
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

28
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
28
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.2K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.2K
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

53
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
53

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk of Developing Seizures in Children With Abnormal EEG Findings During Polysomnography.

Pediatric neurology·2023
Same author

A Case Report of Myelopathy Following Heroin Overdose in a Child.

Child neurology open·2021
Same author

Safety and Efficacy of Brivaracetam in Pediatric Refractory Epilepsy: A Single-Center Clinical Experience.

Journal of child neurology·2019
Same author

A case report of hypersomnia in tetrasomy X improved with medical therapy.

Clinical case reports·2018
Same author

Introduction.

Seminars in pediatric neurology·2018
Same author

Tremors: Essential Tremor and Beyond.

Seminars in pediatric neurology·2018
Same journal

Concussion in contact sport: risks, detection, & prevention.

Seminars in pediatric neurology·2026
Same journal

A multidisciplinary, symptom-targeted approach to rehabilitation in pediatric concussion.

Seminars in pediatric neurology·2026
Same journal

Pediatric concussion beyond sports: Falls, play, and everyday activities.

Seminars in pediatric neurology·2026
Same journal

Return-to-school protocols in pediatric concussion care.

Seminars in pediatric neurology·2026
Same journal

Improving concussion recognition in youth sports: the role of parents, coaches, and community education.

Seminars in pediatric neurology·2026
Same journal

Concussion management, rehabilitation, and societal impact.

Seminars in pediatric neurology·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Author Spotlight: Decoding Mitochondrial Aging
08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

6.3K

Mitochondrial dysfunction in demyelinating diseases.

Karen S Carvalho1

  • 1Section of Neurology, St. Christopher's Hospital for Children, Philadelphia, PA; Departments of Pediatrics and Neurology, Drexel University College of Medicine, Philadelphia, PA.

Seminars in Pediatric Neurology
|December 17, 2013
PubMed
Summary
This summary is machine-generated.

Mitochondrial dysfunction drives neuroinflammation and neurodegeneration in demyelinating diseases like multiple sclerosis. Understanding this link may reveal new neuroprotective therapies for these conditions.

More Related Videos

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

1.9K
Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.4K

Related Experiment Videos

Last Updated: May 4, 2026

Author Spotlight: Decoding Mitochondrial Aging
08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

6.3K
Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

1.9K
Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.4K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Immunology

Background:

  • Mitochondrial (mt) dysfunction is implicated in neurodegenerative disorders, particularly demyelinating diseases.
  • Neuroinflammation, a hallmark of these conditions, exacerbates mt dysfunction and neuronal damage.
  • Conversely, mt failure amplifies neuroinflammation, creating a detrimental cycle.

Purpose of the Study:

  • To explore the intricate relationship between mitochondrial dysfunction and neuroinflammation in progressive demyelinating diseases.
  • To investigate the role of mt failure in the pathogenesis and progression of conditions like multiple sclerosis and X-linked adrenoleukodystrophy.
  • To identify potential therapeutic targets for neuroprotection by understanding oxidative stress mechanisms.

Main Methods:

  • Review of emerging research on mitochondrial function in demyelinating diseases.
  • Analysis of the interplay between reactive oxygen species production and neuronal/glial health.
  • Examination of studies linking neuroinflammation to mitochondrial integrity.

Main Results:

  • Mitochondrial dysfunction is a key factor in the progression of neuroinflammation and neurodegeneration.
  • Neuroinflammation contributes significantly to mitochondrial failure in demyelinating conditions.
  • A bidirectional relationship exists between mitochondrial health and inflammatory processes.

Conclusions:

  • Mitochondrial dysfunction and neuroinflammation are closely intertwined in progressive demyelinating diseases.
  • Targeting oxidative stress and mitochondrial pathways may offer novel neuroprotective strategies.
  • Further research is crucial for developing effective treatments for severe neurological disability caused by these diseases.