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Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
Published on: May 23, 2025
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Primary leptomeningeal melanoma
Zhao-Yu Xie1, Kevin Li-Chun Hsieh1, Yuk-Ming Tsang1
1Department of Radiology, Division of Medical Imaging, Far Eastern Memorial Hospital, Number 21, Section 2, Nanya S. Road, Banqiao District, New Taipei City 220, Taiwan.
Summary
Primary leptomeningeal melanoma, a rare brain tumor, can cause seizures. This case study details a successful surgical removal of an intracranial tumor, with no recurrence observed in follow-up imaging.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Pathology
Background:
- Primary melanoma of the central nervous system (CNS) is an exceptionally rare melanocytic neoplasm.
- These tumors typically arise within the leptomeninges, the membranes surrounding the brain and spinal cord.
Observation:
- A 57-year-old woman presented with myoclonic seizures, indicative of neurological distress.
- Radiological imaging, including CT scans and MRI, identified an intracranial hemorrhagic tumor.
Findings:
- Surgical resection achieved complete tumor removal.
- Pathological examination confirmed the diagnosis of leptomeningeal melanoma.
- Post-operative imaging over 19 months revealed no evidence of disease recurrence.
Implications:
- This case highlights the importance of considering rare CNS tumors in the differential diagnosis of seizures.
- Complete surgical excision appears to be an effective treatment strategy for intracranial leptomeningeal melanoma.
- Further research into the characteristics and management of these rare tumors is warranted.
