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Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor

Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor

Published on: June 14, 2011

Vessel bioengineering.

Shuhei Tara¹, Kevin A Rocco, Narutoshi Hibino

¹Nationwide Children's Hospital.

Circulation Journal : Official Journal of the Japanese Circulation Society

|December 17, 2013

Summary

Tissue-engineered vascular grafts (TEVG) show promise for cardiovascular disease. However, small-diameter arterial TEVG (<6mm) face challenges, requiring collaboration for clinical success.

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Published on: June 14, 2011

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Published on: December 10, 2020

Area of Science:

Biomedical Engineering
Regenerative Medicine
Cardiovascular Research

Background:

Vascular bioengineering offers novel treatments for cardiovascular disease.
Tissue-engineered vascular grafts (TEVG) utilize biodegradable scaffolds and autologous cells for in situ neovascularization.
TEVG have shown clinical viability in congenital heart defect patients.

Purpose of the Study:

To review the development and challenges of tissue-engineered vascular grafts (TEVG) for arterial applications.
To highlight the requirements for arterial scaffolds and the role of cell sources in TEVG.
To identify barriers to the clinical translation of small-diameter arterial TEVG.

Main Methods:

Review of biodegradable synthetic polymers and natural materials for arterial scaffolds.
Analysis of various cell sources (somatic cells, stem cells) used in TEVG.
Examination of clinical effectiveness data for small-diameter arterial TEVG.

Main Results:

Biodegradable scaffolds, from synthetic polymers or natural materials, can meet arterial pressure requirements.
Diverse cell types are employed in TEVG, influencing tissue remodeling.
Clinical effectiveness of small-diameter arterial TEVG (<6mm) remains a significant challenge.

Conclusions:

Successful clinical translation of arterial TEVG requires overcoming challenges in small-diameter applications.
Interdisciplinary collaboration among biologists, engineers, and clinicians is essential for advancing TEVG technology.
Further research is needed to improve the performance and reliability of arterial TEVG.