Related Experiment Video
Updated: May 4, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
Published on: May 10, 2018
Evaluation of insulin secretion and sensitivity in a patient with slowly progressive type 1 diabetes mellitus
Toshiharu Ishizuka1, Yoshiharu Tokuyama, Azuma Kanatsuka
1Credo Sato Clinic, Japan.
Abstract:
We herein report the case of a patient with slowly progressive type 1 diabetes and insulin independence lasting for >10 years despite the detection of continuously elevated glutamic acid decarboxylase autoantibody titers. We monitored the patient's clinical course and analyzed his endogenous insulin secretion and sensitivity using an intravenous glucose tolerance test (IVGTT) and oral glucose tolerance test (OGTT). His body mass index remained at approximately 22, while his serum C-peptide immunoreactivity level gradually decreased. The level of insulin secretion was significantly higher on the OGTT than the IVGTT. The patient's insulin sensitivity was within the normal limits. These results suggest that maintaining a lifestyle sufficient to preserve insulin secretion and/or normal insulin sensitivity is important and that β-cell responsiveness to incretins may, in part, contribute to insulin independence.
Related Concept Videos
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Type II Diabetes II: Pathophysiology
Type I Diabetes III: Clinical Manifestations
Type I Diabetes I: Introduction
Type I Diabetes II: Pathophysiology

