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Characteristics of neonatal GBS disease during a multicentre study (2007-2010) and in the year 2012

Roberta Creti1, Alberto Berardi, Lucilla Baldassarri

  • 1Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Rome, Italy.

Annali Dell'Istituto Superiore Di Sanita
|December 17, 2013
PubMed

Insights

Group B Strep infections in newborns can be reduced by improving intrapartum antibiotic prophylaxis adherence. Strategies like CDC recommendations can lower early-onset disease incidence.

Area of Science:

  • Neonatal infections
  • Bacterial pathogenesis
  • Public health surveillance

Background:

  • Group B Streptococcal (GBS) infections pose a significant threat to newborns.
  • Understanding the characteristics of early-onset (EOD) and late-onset (LOD) GBS neonatal infections is crucial for effective prevention.
  • Italian GBS infection surveillance data from 2007-2010 (mandatory) and 2012 (voluntary) were analyzed.

Purpose of the Study:

  • To analyze the characteristics of GBS EOD and LOD in Italy.
  • To identify risk factors associated with neonatal GBS infections.
  • To evaluate the effectiveness of prevention strategies and identify areas for improvement.

Main Methods:

  • Data collection using standardized forms for maternal and neonatal cases.
  • Comparative analysis of GBS infection characteristics between two surveillance periods.
  • Identification of common risk factors for EOD.

Main Results:

  • Preterm deliveries, precipitous labor, and GBS-negative maternal screening were common in EOD cases.
  • Inadequate or absent intrapartum antibiotic prophylaxis is a likely contributor to EOD.
  • Analysis of GBS neonatal disease characteristics across different reporting periods.

Conclusions:

  • Improving adherence to prevention strategies, such as CDC recommendations, is essential.
  • Enhanced intrapartum antibiotic prophylaxis can reduce GBS EOD incidence.
  • Continued efforts are needed to minimize GBS prevention failures in newborns.
Abstract

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