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Vitamin D supplementation increases calcium absorption without a threshold effect.

John F Aloia1, Ruban Dhaliwal, Albert Shieh

  • 1From Winthrop University Hospital, Mineola, NY (JFA, RD, AS, MM, MF, and LR) and Baylor College of Medicine, Houston, TX (SAA).

The American Journal of Clinical Nutrition
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Summary
This summary is machine-generated.

Maximal calcium absorption does not appear to have a threshold with increasing vitamin D. This study found that calcium absorption increases linearly with vitamin D dosage and serum 25-hydroxyvitamin D levels.

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Bone Metabolism

Background:

  • Vitamin D sufficiency is often assessed by maximal calcium absorption.
  • The existence of a threshold for vitamin D's effect on calcium absorption is debated.

Purpose of the Study:

  • To investigate if increasing vitamin D doses or serum 25-hydroxyvitamin D [25(OH)D] concentrations lead to a plateau in calcium absorption.
  • To determine if a threshold exists beyond which calcium absorption no longer increases.

Main Methods:

  • A randomized, double-blind, placebo-controlled, dose-response study.
  • Healthy postmenopausal women received placebo or varying doses of vitamin D₃ (800, 2000, or 4000 IU) for 8 weeks.
  • Calcium absorption was measured using dual stable calcium isotopes.

Main Results:

  • A statistically significant linear trend showed increased calcium absorption with higher vitamin D₃ doses and serum 25(OH)D levels.
  • No evidence of a threshold or nonlinearity was observed in the dose-response curve.
  • The highest vitamin D₃ dose group showed a 6.7% absolute increase in calcium absorption.

Conclusions:

  • No threshold for calcium absorption was identified within the tested serum 25(OH)D range (40-130 nmol/L).
  • Calcium absorption is not a reliable biomarker for establishing vitamin D nutritional recommendations within this range.