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Correlations between 18F-FDG PET/CT parameters and pathological findings in patients with rectal cancer
Chih-Ying Liao1, Shang-Wen Chen, Yi-Chen Wu
1From the *Department of Radiation Therapy and Oncology, Taichung Hospital, Department of Health, Executive Yuan; †Department of Radiation Oncology, China Medical University Hospital, Taichung; ‡Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung; §College of Medicine, Taipei Medical University, Taipei; ¶Department of Nuclear Medicine, E-Da Hospital/I-Shou University, Kaohsiung; and ∥Department of Surgery, China Medical University Hospital; **Department of Nuclear Medicine and PET Center, China Medical University Hospital; ††Department of Biomedical Imaging and Radiological Science, China Medical University; and ‡‡Department of Pathology, China Medical University Hospital, Taichung, Taiwan.
Purpose:
This study examined the correlations between F-FDG PET/CT results and tumor specimen pathology in patients with rectal cancer.
Methods:
Sixty-seven patients with rectal cancer who had received preoperative PET/CT were included in this study. Autosegmentation methods were used to determine the maximum PET/CT-based tumor length (TL), tumor width (TW), and metabolic tumor volume for each patient. The TL and TW values were compared with the maximum pathological length and width of the tumor specimen. To forecast the pathological T and N stages, a receiver operating characteristic curve was created for each parameter to evaluate its predictive ability. Logistic regression analysis was used to identify the predictors of pathology.
Results:
The values of 30% of maximum uptake for TL and 40% of maximum uptake for TW provided the best match with the maximum pathological tumor length and width (Pearson r = 0.72, P < 0.001; r = 0.44, P < 0.001, respectively). Metabolic tumor volume with a fixed threshold of 2.5 emerged as an independent factor for predicting the pathological T3 or T4 stage (P = 0.001; odds ratio, 1.81; 95% confidence interval, 1.26-2.60).
Conclusions:
Preoperative PET/CT can be used as a supplemental tool in predicting pathological findings for patients with rectal cancer requiring operation.
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