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Prostate cancer, version 1.2014.

James L Mohler1, Philip W Kantoff, Andrew J Armstrong

  • 1From 1Roswell Park Cancer Institute; 2Dana-Farber/Brigham and Women's Cancer Center; 3Duke Cancer Institute; 4The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; 5Huntsman Cancer Institute at the University of Utah; 6Memorial Sloan-Kettering Cancer Center; 7Fred & Pamela Buffett Cancer Center at The Nebraska Medical Center; 8Prostate Health Education Network; 9University of Washington/Seattle Cancer Care Alliance; 10Fox Chase Cancer Center; 11City of Hope Comprehensive Cancer Center; 12Massachusetts General Hospital Cancer Center; 13Robert H. Lurie Comprehensive Cancer Center of Northwestern University; 14Vanderbilt-Ingram Cancer Center; 15University of Michigan Comprehensive Cancer Center; 16Moffitt Cancer Center; 17St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; 18UCSF Helen Diller Family Comprehensive Cancer Center; 19The University of Texas MD Anderson Cancer Center; 20Patient Advocate; 21Stanford Cancer Institute; 22Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; 23The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; and 24National Comprehensive Cancer Network.

Journal of the National Comprehensive Cancer Network : JNCCN
|December 17, 2013
PubMed
Summary
This summary is machine-generated.

Recent NCCN Guidelines for Prostate Cancer updates include a Category 1 recommendation for Radium-223 dichloride in bone metastasis treatment. Recommendations for intermittent versus continuous androgen deprivation therapy were also revised.

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Area of Science:

  • Oncology
  • Radiopharmaceutical Therapy
  • Clinical Practice Guidelines

Background:

  • The National Comprehensive Cancer Network (NCCN) provides evidence-based guidelines for cancer care.
  • Prostate cancer management requires up-to-date clinical recommendations.
  • Recent advancements necessitate guideline revisions.

Purpose of the Study:

  • To summarize key updates to the NCCN Guidelines for Prostate Cancer.
  • To highlight new treatment options and revised therapeutic strategies.

Main Methods:

  • Review of recent clinical trial data and expert panel consensus.
  • Analysis of newly approved therapies for prostate cancer.
  • Evaluation of androgen deprivation therapy strategies.

Main Results:

  • Radium-223 dichloride received a Category 1 recommendation for symptomatic bone metastases without visceral disease, usable as first- or second-line therapy.
  • NCCN Prostate Cancer Panel revised recommendations for intermittent vs. continuous androgen deprivation therapy based on Phase III data.

Conclusions:

  • Updated NCCN Guidelines offer refined treatment pathways for prostate cancer.
  • Radium-223 dichloride represents a significant advancement in managing bone metastases.
  • Evidence-based revisions guide the optimal use of androgen deprivation therapy.